As of February 2019, the university is using a two factor VPN. Information and instructions for this VPN are available here: https://www1.ucdenver.edu/offices/office-of-information-technology/service-projects/cu-secure-multi-factor-authentication
University copies of Microsoft Office are available through Webmail and limited to 5 licenses per user.
To download office, log into your webmail and click on the "Office 365" link on the upper left. On the next page, there is a link to "Install Office" on the upper right.
Matlab is now maintained by CU Denver OIT and information on acquiring it is available here: https://www1.ucdenver.edu/offices/office-of-information-technology/software/how-do-i-use/matlab
Mathematica is maintained by CU Boulder OIT and is available here: https://oit.colorado.edu/software-hardware/site-licenses/mathematica
R is freeware and is available here: https://www.r-project.org/